Establishment of a fabrication method for a long-term actuated hybrid cell robo..... (DOI: 10.1039/b705367c)
A collaboration between scientists at the Nano-Bio Research Center, Korea Institute of Science and Technology in Korea, the School of Electrical Engineering, Seoul National University in Korea, The Whitaker Institute for Biomedical Engineering at Johns Hopkins University in Maryland USA, the School of Aerospace & Mechanical Engineering at Hankuk Aviation University in Korea, the School of Life Sciences and Biotechnology at Korea University, and the School of Mechanical Systems Engineering at Chonnam National University in Korea has resulted in the following conclusions:
"By growing rat muscle tissue onto a polymer backbone, the movement of a cell-powered microrobot was demonstrated for the first time. The most significant results from this study are as follows. (1) Our microrobot was a self-assembled hybrid consisting of biotic muscle cells and a PDMS backbone—a well-known biocompatible material. (2) The surface of the PDMS backbone was engineered with a 3D grooved pattern that led to high-order cell concentrations and enabled a high generative force from the muscle cells. (3) The PDMS was easily fabricated by using a micromolding procedure thus allowing for high throughput and mass-production of cell-powered microrobots. (4) This is the first report describing the results of long-term monitoring of primary cultured cardiomyocytes on microrobots. A potential application for the microrobot developed in this study may be to work for certain periods of time within small lumens or vessels or ducts, perhaps to remove various types of blockages which have accumulated in the ducts when the degradable elaborated microrobot is finally aimed to the blockages. By injecting or inserting into the ducts, the microrobot will survive and actively engage in beating movement along the length of the duct and some types of dissolving agent could be contained in the microrobot to clear the blockages."